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Hypertrophy of bladder wall smooth muscle; increased risk for bladder diverticula 5 medicine journal safe disulfiram 250mg. Risk factors include age medicine plus cheap 250 mg disulfiram, race (African Americans> Caucasians> Asians) medications nursing buy 250mg disulfiram, and diet high in saturated fats medications 2 generic 250mg disulfiram. Usually arises in the peripheral, posterior region of the prostate and, hence, does not produce urinary symptoms early on. Multiple regions of the tumor are assessed because architecture varies from area to area. A score (1- 5) is assigned for two distinct areas and then added to produce a final score (2- 10). Prolactinoma presents as galactorrhea and amenorrhea (females) or as decreased libido and headache (males); most common type of pituitary adenoma l. Insufficient production of hormones by the anterior pituitary gland; symptoms arise when > 75% of the pituitary parenchyma is lost. Pituitary adenomas (adults) or craniopharyngioma (children)-due to mass effect or pituitary apoplexy (bleeding into an adenoma) 2. Gland doubles in size during pregnancy, but blood supply does not increase significantly; blood loss during parturition precipitates infarction. Oxytocin mediates uterine contraction during labor and release of breast milk (let-down) in lactating mothers. Clinical features are similar to central diabetes insipidus, but there is no response to desmopressin. Mental status changes and seizures-Hyponatremia leads to neuronal swelling and cerebral edema. Thyroid develops at the base of tongue and then travels along the thyroglossal duct to the anterior neck. Thyroglossal duct normally involutes; a persistent duct, however, may undergo cystic dilation. Increases sympathetic nervous system activity (due to increased expression of receptors) B. Irregular follicles with scalloped colloid and chronic inflammation are seen on histology. Due to elevated catecholamines and massive hormone excess, usually in response to stress. Characterized by mental retardation, short stature with skeletal abnormalities, coarse facial features, enlarged tongue, and umbilical hernia l. Causes include maternal hypothyroidism during early pregnancy, thyroid agenesis, dyshormonogenetic goiter, and iodine deficiency. Clinical features are based on decreased basal metabolic rate and decreased sympathetic nervous system activity. Myxedema-accumulation of glycosaminoglycans in the skin and soft tissue; results in a deepening of voice and large tongue 2. Bradycardia with decreased cardiac output, leading to shortness of breath and fatigue 7. Most common causes are iodine deficiency and Hashimoto thyroiditis; other causes include drugs. Most common cause of hypothyroidism in regions where iodine levels are adequate B. Antithyroglobulin and antimicrosomal antibodies are often present (sign of thyroid damage). Chronic inflammation with germinal centers and Hurthle cells (eosinophilic metaplasia of cells that line follicles) is seen on histology. Malignant proliferation of follicles surrounded by a fibrous capsule with invasion through the capsule. Invasion through the capsule helps distinguish follicular carcinoma from follicular adenoma. Malignant proliferation of para follicular C cells; comprises 5% of thyroid carcinomas l. Calcitonin lowers serum calcium by increasing renal calcium excretion but is inactive at normal physiologic levels. Increases small bowel absorption of calcium and phosphate (indirectly by activating vitamin D) 3.

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